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It’s not usual for Twitter to be offline and not even seeing the fail whale on a page. Nothing from the website will load. I first noticed at around 12:30 A.M. today, June 22, 2012.
A quick Google search led me to a scoop post by The Verge:
Twitter appears to be down for users across the US and other countries. Members of our staff in both the US and UK cannot access Twitter.com, and the social network’s APIs appear to be offline, too: first-party and third-party apps are both unable to send or receive tweets. It’s not rare for Twitter’s website to experience difficulties (also known as the fail whale), but the company’s website is unable to load at all at this time. It’s very rare for the social network’s APIs to break, though it appears to be coming and going. If you simply must send a tweet, mobile.twitter.com seems to be loading up just fine. We’ve reached out to Twitter to see what the problem is, and we’ll update this post when we hear more.
Twitter is still down as of posting this at 12:54 A.M. (+8 GMT), June 22, 2012.